TNFRSF25 and colonic neoplasm: In agreement with these findings, the decreased expression of cleaved caspase-3 protein by tectochrysin (Fig. 3b) and DNA binding activity of NF-κB by tectochrysin were also abolished in SW480 and HCT116 colon cancer cells treated with DR3, DR4 and Fas siRNA (Fig. 3c).