SPP1 and neoplasm: Kim J and coworkers determined plasma levels of OPN (ELISA), as well as AFP and PIVKA II, in 62 patients with HCC (69 % HBV, 10 % HCV, 3 % alcohol related), in 60 patients with chronic liver disease without tumor (83 % HBV, HCV 3 %, 10 % alcohol related) and in 60 healthy controls.