The difference between results of OPN in the chronic liver disease (CLD) group in the study of Kim J et al. (median 381 ng/mL; limits: 29–1688) and our (median: 946.30 ng/mL; limits: from 337.10 to 3583.00) may be due to the fact that they had only 50 % of cirrhosis in the CLD group, while in our case, all the patients had cirrhosis (and thus greater severity of liver disease). Here, SPP1 is linked to Cirrhosis.