SPP1 and alcoholic liver diseases: As previously said, we do not have histological data from the time when blood draws for OPN assays were collected, and in fact we only have liver biopsy in 26 patients (28,9 %), which is a limitation of our study and that’s why we could not exclude accompanying inflammatory processes, which deserves further research aimed to better characterize the role of alcoholic liver disease on the plasma levels of OPN.