PDE5A and pulmonary arterial hypertension: Remarkably, in addition to the favorable actions onto PAH, PDE5 inhibition exerts cardioprotective effects as documented in different cardiac pathologies: from heart failure (HF), where sildenafil improves cardiac kinetics [64], to ischemia/reperfusion injuries, where it ameliorates vascular perfusion/density and tissue blood flow, to infarct, where it reduces damage size, apoptotic processes and cardiac hypertrophy, to ventricular arrhythmias, where it reduces disease severity, to cardiopulmonary bypass, where it increases coronary blood flow and cardiac recovery [3, 60, 61, 63].