TNFRSF13B and common variable immunodeficiency: Other TNFRSF13B variants (p.P251L, p.V220A, p.R202H and p.R72H) have originally been linked to CVID, but a later study found equal frequencies in CVID patients and healthy controls as we found here (as compared to the frequency in the 1000 genomes project and the non-CVID WGS500 samples) [24–26,41].