Fig. S6 shows the increased expression of ITGB2, a described PID gene, and ICAM1, which interacts with three CVID related genes (NLRP12, CD81, PLCG2). We also identified variants linked to reduced gene expression (n = 116, chi squared p value < 0.0001, Table S10). These include SH3BP2 which interacts with and activates other CVID and PID genes and VPREB3 which is involved in B-cell development (Fig. S6) [67,68]. No variants linked to altered gene expression are found in the regions associated with CVID identified by GWAS [30]. Here, VPREB3 is linked to common variable immunodeficiency.