Mutations in CD27 [13, 14], PLCG2 [15,16], LRBA [17,18], NFKB2 [19,20], PIK3CD [21,22] and NLRP12 [23] cause CVID-like symptoms often combined with a more extensive clinical phenotype (Table S1). Here, NLRP12 is linked to common variable immunodeficiency.