INS and major depressive disorder: For example, skeletal muscle represents a major organ for glucose homeostasis, responsible for up to 75% of post-prandial (that is, insulin-stimulated) glucose uptake.27 Low muscle mass might therefore be expected to impair glucose homeostasis and various studies have shown a link between glycaemic control and depression.28, 29, 30 In previous work on obese adolescents with type 2 diabetes, brain abnormalities, such as reduced white matter volume and enlarged cerebrospinal fluid space, have been found, which might result from changes in vascular function and glucose abnormalities.31