Moreover, an increased likelihood of LNM and higher histological grade were correlated with high Notch1 expression in breast cancer (pooled OR = 1.65, 95%CI: 1.09–2.52, p = 0.064 and I2 = 55%; pooled OR = 1.68, 95%CI: 1.28–2.2, p = 0.737 and I2 = 0.0%) (Fig 2C and 2D). The gene discussed is NOTCH1; the disease is breast cancer.