Compared to uninfected HFF cells, where BRCA1 was associated with IFI16 only in the nucleus (Fig 13B, green PLA spots) as IFI16 was predominantly present in the nucleus (Fig 13A, green PLA spots), some of the IFI16 and IFI16-BRCA1 PLA spots colocalized with Edu-HSV-1 genome in the nucleus within 30 min of infection (white arrows, Fig 13D and 13E; left and also rightmost panels). The gene discussed is IFI16; the disease is infection.