BRCA1 and primary effusion lymphoma: Our studies demonstrating that IFI16-BRCA1 functions as an innate sensor of KSHV, EBV and HSV-1 genomes in non-immune professional cells, such as endothelial, epithelial and fibroblast cells, and in B-lymphoma cell lines as well as the IFI16 and ASC interactions in tissue sections from PEL and KS patients [3], clearly suggested that these cells have evolved to respond to danger signals.