Although BRCA1 was observed in the nucleus and in the cytoplasm of both uninfected and infected cells, BRCA1 levels in the cytoplasm of infected cells increased during the observed periods (0.5 h, 4 h and 24 h) of infection similar to that of IFI16 (Fig 3A, panels 1 and 2, lanes 1 to 8). The gene discussed is BRCA1; the disease is infection.