Fig 3A showing KSHV infection induced cytoplasmic distribution of a fraction of nuclear resident BRCA1 and IFI16 coupled with the observed increase in co-IP of BRCA1 and IFI16 in the nuclear as well as the cytoplasmic fractions during virus infection (Fig 3B and 3C) suggest that BRCA1-IFI16 association in the nucleus increase perhaps to sense the viral genome which is followed by the BRCA1 aided cytoplasmic translocation of IFI16. Here, BRCA1 is linked to viral infectious disease.