CHEK2 and infection: In addition, we also observed only a limited association of BRCA1 with CHK2 and γH2AX (Fig 2D, 3rd row, 2nd and 3rd blocks) and no overall interaction of IFI16 with CHK2 and γH2AX during infection (Fig 2D, 3rd row, 5th and 6th blocks; S1 Table).