As expected, cleaved Caspase-1 and mature IL-1β were observed in BRCA1 expressing but not in BRCA1 negative HCC 1937 cells during either the early or late period post-KSHV infection (Fig 8D, panel 2 and 3, lanes 6–8 vs lanes 1–5). This evidence concerns the gene IL1B and hepatocellular carcinoma.