IFI16 and viral infectious disease: Fig 3A showing KSHV infection induced cytoplasmic distribution of a fraction of nuclear resident BRCA1 and IFI16 coupled with the observed increase in co-IP of BRCA1 and IFI16 in the nuclear as well as the cytoplasmic fractions during virus infection (Fig 3B and 3C) suggest that BRCA1-IFI16 association in the nucleus increase perhaps to sense the viral genome which is followed by the BRCA1 aided cytoplasmic translocation of IFI16.