Similar to the IFI16-BRCA1 complex involved in pathogen DNA recognition, inflammasome induction and IFN-β production shown here, it is possible that IFI16 could be forming distinct complexes with different proteins and each complex could be mediating distinct functions, such as transcription and other responses, which may differ between various virus nuclear lytic and latent infections and as per host cell types. The gene discussed is IFI16; the disease is disease arising from reactivation of latent virus.