To further confirm the active involvement of BRCA1 in KSHV induced inflammasome activation, we transduced BRCA1– HCC cells with lentiviruses expressing BRCA1 (Fig 8D, panel 1, lanes 5–8) or control lentiviruses (Fig 8D, panel 1, lanes 1–4). The gene discussed is BRCA1; the disease is hepatocellular carcinoma.