SLC5A1 and diabetic cardiomyopathy: Moreover, Banerjee et al. demonstrated that the SGLT1 expression is increased under both conditions of ischemic or diabetic cardiomyopathy, possibly as an adaptive response to cardiac damage [10], while the same group and others reported that chronic excessive activation of cardiac SGLT1 has unfavorable effects [31,32], thus suggesting that the time course of SGLTs activation is critical for eliciting cardioprotective effects.