Patients in ETV group and LAM group with a high HBV DNA level had similar age, gender, serum ALT levels, serum HBV DNA levels before SCC, status of HBeAg, and duration of antiviral prophylaxis while patients in ETV group had a higher proportion of hepatoma and liver cirrhosis than patients in LAM group (58.8% vs. 17.7%; P < 0.001 and 52.9% vs. 17.7%; P < 0.001, respectively). This evidence concerns the gene GPT and hepatocellular carcinoma.