The IPA identified the hepatic fibrosis/hepatic stellate cell activation (p≤5.41E-17), acute phase response signaling (p≤3.14E-13), role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis (p≤1.36E-11), IGF1 signaling (p≤5.83E-11) and leukocyte extravasation signaling (p≤2.47E-09) pathways. The gene discussed is IGF1; the disease is rheumatoid arthritis.