BRAF and neoplasm: The aim of the study was: i: To describe the true incidence of BRAF mutations in unselected mCRC patients, ii: To investigate if BRAF mutations alone could explain the very poor prognosis for mCRC patients with poor PS, iii: To characterize patients without available tumor tissue for molecular analyses, to decide generalizability of prior TMA studies, and iv: To study heterogeneity of survival for unselected mCRC patients in comparison to selected trial patients.