SIRT3 and pancreatic ductal adenocarcinoma: This study has shed light on the potential use of sirtuins in the prognosis and stratification for patients with pancreatic ductal adenocarcinoma, with both SIRT3 and SIRT7 appearing to possess tumour suppressor properties The complexity of sirtuin biology is becoming increasingly apparent, as is the fact that the sirtuins play a crucial role in tumourigenesis, whether it be preventing or initiating cellular transformation, or functioning to maintain a tumourigenic phenotype.