Subjects bearing 3 and 4 risk factors displayed significantly lower eGFR, adiponectin, CML/Alb and sRAGE levels; and higher uric acid, hsCRP, leptin, resistin, and AGE-Fl/Alb levels in comparison with the risk factors-free subjects. This evidence concerns the gene RETN and chronic myelogenous leukemia, BCR-ABL1 positive.