NPC1 and diabetes mellitus: The strengths of this study are that it represents i) the first time four non-synonymous NPC1 polymorphisms have been investigated in a multiethnic study and shown to be associated with increased risk for select measures of adiposity and diabetes, ii) the first time these NPC1 polymorphisms have been investigated in the context of pregnancy, and iii) the first time these NPC1 polymorphisms have been investigated with assessment of linkage-disequilibrium.