NFE2L2 and fatty liver disease: Rodent studies suggest that Nrf2 has a dual protective role in the progression from hepatic steatosis to steatohepatitis: (i) the negative regulation of genes that promote lipid accumulation in hepatocytes (“first hit”), likely by a combination of mechanisms that remain poorly understood; (ii) the activation of genes that promote the elimination of ROS and electrophiles derived from lipid peroxidation, thus preventing hepatocellular oxidative stress and mitochondrial dysfunction (“second hit”).