Similarly, common polymorphisms associated with blood lipoprotein concentrations are often located in the genomic vicinity of genes associated with Mendelian disorders of lipoprotein metabolism, such as ABCG8, LCAT, APOB, LDLR, PCSK9, CETP, LPL, LIPC, and ABCA1. 57,58 We therefore reasoned that the phenotypic-genetic overlap might be a general tendency for rare and common diseases located at the same genetic locus. The gene discussed is LDLR; the disease is metabolic process.