AICDA and malaria: Recent advancements in gene editing using the CRISPR-Cas9 system and a report implying activity of the AID system in P. falciparum (Ghorbal et al., 2014; Kreidenweiss et al., 2013; Wagner et al., 2014) should permit application of the degradation technology to effectively examine endogenous protein function in the human malaria parasite.