In 2007, a study by Manabe and colleagues pointed at a role of HMGA1 during exon-skipping of presenilin-2 pre-mRNA, which results in the production of a deleterious protein isoform found in brains of patients suffering from Alzheimer’s disease, and thus provided first evidence for a specific RNA affinity of HMGA1 [34]. Here, HMGA1 is linked to Alzheimer disease.