HMGA1 and cancer: Given the strong overexpression of HMGA1 in the vast majority of cancers and its causal effects during malignant transformation, the negative regulation of HMGA1 function by overexpressing 7SK Loop2 RNA or full length 7SK RNA might serve as a reasonable alternative or complement for HMGA1-targeting anticancer therapeutic approaches such as small interfering (si)RNA-mediated HMGA1 knockdown [16].