HMGA1 has been previously implicated in HIV-1 infection as a host cellular co-factor recruiting the nucleosome remodeling complex SWI/SNF to the HIV-1 LTR, being involved in HIV-1 splice site regulation and contributing to the HIV-1 pre-integration complex [45,46,47,48,49,50]. This evidence concerns the gene HMGA1 and HIV-1 infection.