TP53 and cancer: Interestingly, among them were multidrug-resistant cell lines, e.g., P-glycoprotein overexpressing CEM/ADR5000, breast cancer resistance protein-transfected MDA-MB-231-BCRP, TP53 knockout cells (HCT116 p53−/−), and mutation-activated epidermal growth factor receptor-transfected U87MG.ΔEGFR cells [88].