However, hyperglycaemia is frequently observed with PI3Kα inhibitors such as BYL719 and GDC-0032 [22, 23], in contrast to δ and γ isoform-specific PI3K inhibitors for which myelosuppression with neutropenia and raised liver transaminases have been reported, whereas hyperglycaemia is relatively uncommon [8, 9••, 10••]. This evidence concerns the gene PIK3CA and Hyperglycemia.