NCOR1 and chronic myelogenous leukemia, BCR-ABL1 positive: In the first instance we examined the changes in gene expression following NCOR1 knockdown and revealed that the knockdown of NCOR1 modulated sensitivity to Imatinib induced differentiation in K562 cells, and these gene expression patterns were significantly enriched in both the Imatinib-dependent gene signature of K562 cells and in CML cells from patients who were sensitive to Imatinib.