PTEN and chronic myelogenous leukemia, BCR-ABL1 positive: In order to evaluate, in K562 and LAMA84 cells, if downregulation of PTEN expression in miR-21 mimic transfected cells was reverted after the addition of Curcumin, we treated the miR-21 mimic transfected CML cells with 20 μM Curcumin.