On the contrary in K562 and LAMA84 cells transfected with miR-21 inhibitor and treated with Curcumin, we observed a higher increase of PTEN mRNA expression than CML cells transfected with miR-21 inhibitor alone (Figure 4d, white bars). The gene discussed is PTEN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.