AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: To elucidate the effect of Curcumin treatment on AKT pathway in CML cells, we showed, by ELISA assay (Figure 5a and b) and western blot analyses (Figure S2a and S2b), that the addition of Curcumin, for 24 h, caused a dose-dependent decrease of AKT phosphorylation in CML cell.