Injection of 3 ng of MO-huG in zebrafish embryos led to a similar but weaker cardiac phenotype to that observed after depletion of rbfox1. Specifically, MO-huG-injected embryos developed late-onset heart failure with dilation of the both chambers and pericardial edema (Fig. 6A; supplementary material Movie 3). Here, RBFOX1 is linked to heart failure.