Adenovirally expressed TIMP3 stabilzes tumor necrosis factor receptor-1 (TNF-R1), FAS, and TNF-related apoptosis, inducing ligand receptor-1 (TRAIL-R1) on melanoma cell surface, sensitizing these cells to apoptosis induced by TNF-α, anti-FAS-antibody and TRAIL [83]. Here, TIMP3 is linked to melanoma.