Because binding sites are excessively expressed in ECM and on proliferating myofibroblasts, we investigated the suitability of iodine-123-labeled galectin-3 (IG3) as a single-photon emission computed tomography (SPECT) probe for myocardial remodeling imaging in a rodent model of post-MI HF. This evidence concerns the gene LGALS3 and hydrops fetalis.