CYCS and viral infectious disease: It showed how the normal cell changed to malignant behavior even metastasis potential: under unspecific carcinogenesis conditions like carcinogens, inflammation, radiation, viral infections, intermittent hypoxia which damaged a cell’s oxidative phosphorylation, the structure and function of mitochondria were damaged thus activating a respiratory chain changes (Complex I, II, III, IV) and also cytochrome c release.