Using total-anti-HBc and IgM-anti-HBc as binary classifiers we ran two ROC curves separating: A) Inactive carriers (IC) from chronic-hepatitis-B (CHB) patients (Fig 2a: AUROC of 0.947 (95% CI 0.86–0.97, p<0.0001) for total-anti-HBc and 0.915 (95% CI 0.91–0.99, p<0.0001) for IgM-anti-HBc; B) Treated HBeAg-negative-CHB with SVR from untreated HBeAg-negative-CHB (Fig 2b: AUROCs of 0.947 (95% CI 0.86–0.97, p<0.0001) for total-anti-HBc and 0.915 (95% CI 0.91–0.99, p<0.0001) for IgM-anti-HBc. The gene discussed is KRT88P; the disease is chronic hepatitis B virus infection.