Hepatitis-B-Virus (HBV) infection elicits a prominent immune response against hepatitis-B-core-antigen (HBcAg) [1–5]: IgG-antibodies against HBcAg (anti-HBc) persist lifelong in HBV exposed individuals whereas IgM-antibodies decline becoming undetectable after recovery from hepatitis-B [4,6–8]. Here, CD40LG is linked to hepatitis B virus infection.