In HBsAg carriers without HBV-induced liver disease (IT, IC and CDH), IgM-anti-HBc (0.06, 0.03–0.61-S/CO) were significantly lower than in untreated CHB patients (0.53, 0.04–27.3-S/CO) (p<0.001). The gene discussed is KRT88P; the disease is liver disorder.