Finally, the findings that total-anti-HBc kinetics correlate with ALT levels as well as IgM-anti-HBc in both naturally-occurring [25–27] and therapy-induced remission and reactivation phases [26,27] support the view that total-anti-HBc is a reliable marker of HBV-induced liver disease in chronic HBsAg-carriers. The gene discussed is KRT88P; the disease is liver disorder.