KRT88P and chronic hepatitis B virus infection: Our data suggest that symmetry or asymmetry of the two markers may have important diagnostic implications: high levels of HBsAg associated with low levels of total-anti-HBc are diagnostic for the immune-tolerance or florid non-inflammatory phase of HBeAg-positive HBV-infection, while high levels of both markers identify chronic hepatitis B (either HBeAg-positive and HBeAg-negative).