Both maternal and cord blood betatrophin levels were significantly higher in the patients with GDM than in the group with NGT (3.45 [2.77–6.53] ng/ml vs 2.78 [2.16–3.65] ng/ml, p = 0.03 and 20.43 [12.97–28.80] ng/ml vs 15.06 [10.11–21.36] ng/ml, p = 0.03, respectively, Fig 3), whereas maternal and cord blood irisin levels did not differ significantly between the two groups (1524 [1261–1783] ng/ml vs 1723 [1460–1988] ng/ml and 1375 [1084–1652] ng/ml vs 1257 [1153–1415] ng/ml, respectively, Fig 4). This evidence concerns the gene FNDC5 and gestational diabetes.