LITAF and Charcot-Marie-Tooth disease: Mutations in lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)/SIMPLE, that interacts with HGS and STAM1 in the ESCRT-0 complex [32,33], cause a demyelinating form of Charcot Marie Tooth disease [34,35], suggesting that ESCRT-0 is required for myelin formation or stability.