APOE and atherosclerosis: In the ApoE–/– atherosclerosis model, brief prenatal exposure to 49 ppm iAs(III) in maternal drinking water was shown to alter the transcriptional profiles in the livers of male mice that were evident at postnatal day (PND) 1 and PND 70; interestingly, the altered mRNA and miRNA profiles differed between these two time points, which is consistent with reprogramming of gene expression profiles in the liver (States et al. 2012).