As FoxP3 and LAG-3 null mice, mice that lack TGF-β present spontaneous autoimmune disease, and depletion of TGF-βR II of T cells resulted in a similar phenotype, but less aggressive, marked by spontaneous activation of T cells, production of autoantibodies and leukocyte infiltrate in multiple organs [57]. Here, LAG3 is linked to autoimmune disease.