To determine whether the effects of the loss of UL13 and US3 kinases on HSV-1 replication is cell-type-dependent, infectious virus production was verified in two additional cell types; namely, the human neuroblastoma SK-N-SH cell line (Fig 8B) and HFF-1 human foreskin fibroblasts (Fig 8C), while Vero cells served as a control (Fig 8A). Here, RPS3 is linked to neuroblastoma.