Likewise, during the infection with the ΔUL13/ΔUS3 mutant, the steady-state levels of glycoprotein D (gD) were reduced such that the levels of precursor gD (pr-gD) were 7-fold lower and mature gD 2-fold lower relative to the HSV-1 KOS (Fig 4B). The gene discussed is ACKR1; the disease is infection.