Despite the downregulation of autophagy markers observed by 7 d post-infection, CYP27B1 and VDR were still significantly upregulated indicating that TLR8 is still sufficiently engaged at these late time posts post-infection (Fig 3C) in the absence of significant cytotoxic effects (P > 0.05; S2G Fig). The gene discussed is TLR8; the disease is infection.