TFEB and infection: Unlike exposure to wild-type HIV, which resulted in the transient dephosphorylation and nuclear translocation of TFEB, infection of macrophages with HIVNL(AD8)ΔNef resulted in the dephosphorylation and increased nuclear translocation of TFEB by 24 h post-infection that lasted throughout the experiment until cells were terminated at 10 d post-infection (Fig 8B).