Since cancer metastasis and invasion are highly related to the degradation of the ECM, intercellular adhesion, and cellular motility, this study explored the effects of HLE on MMPs expression, as well as the activities of Akt, MAPK, and transcriptional factors (AP-1 and NF-κB) on LNCaP (lymph node carcinoma of the prostate) cells, an androgen-responsive human CaP cell line, to explore the underlying mechanism for the action of HLE in cancer cell invasion in vitro. This evidence concerns the gene NFKB1 and cancer.