The transcription factor Myc proto‐oncogene protein (Myc) is thought to be a target of the β‐catenin–Tcf4 transcription complex in CRC cells in vitro, in normal crypts in vivo and in intestinal epithelial cells acutely transformed on in vivo deletion of the Apc gene 59, 87, 88. The gene discussed is APC; the disease is colorectal carcinoma.