Analysis of the common insertion sites for transposon in neoplasms, adenomas and adenocarcinomas revealed that 80% of insertions fell in known CRC genes including APC, FBXW7 (F‐box and WD repeat domain containing 7), PTEN (phosphatase and tensin homolog), and SMAD4, thus validating the approach. The gene discussed is APC; the disease is adenoma.