Inherited maternal UPD14q is associated with Temple Syndrome, characterized by low birth weight, hypotonia, motor delay, early onset of puberty and short adult stature.22 Inherited paternal UPD14q is associated with Kagami–Ogata syndrome, characterized by severe developmental delay, hepatoblastoma and characteristic dysmorphology.23 Both abnormalities result from aberrant expression of the DLK1-MEG3 domain at 14q32, a large and complex imprinted cluster of genes and non-coding RNAs. This evidence concerns the gene MEG3 and Global developmental delay.