Inherited maternal UPD14q is associated with Temple Syndrome, characterized by low birth weight, hypotonia, motor delay, early onset of puberty and short adult stature.22 Inherited paternal UPD14q is associated with Kagami–Ogata syndrome, characterized by severe developmental delay, hepatoblastoma and characteristic dysmorphology.23 Both abnormalities result from aberrant expression of the DLK1-MEG3 domain at 14q32, a large and complex imprinted cluster of genes and non-coding RNAs. Here, MEG3 is linked to multiple congenital anomalies due to 14q32.2 maternally expressed gene defect.