To determine if 14q imprinting abnormalities are more widespread in myeloid neoplasia, MEG3 methylation status was examined in additional MDS/MPN cases (n=96) that had either been analysed by SNP arrays and were known to be negative for aUPD14q (n=48) or were randomly selected without knowledge of their aUPD14 status (n=48). Here, MEG3 is linked to myeloproliferative neoplasm.