GSK3B and early-onset autosomal dominant Alzheimer disease: To observe the effects of chronic curcumin on BDNF, GSK3β and MAPK activation in the Aβ1-42-treated rat model of Alzheimer's disease, a new cohort of animals was injected with curcumin (i.p., once per day) for 7 consecutive days and killed 30 min after the last injection.