Expression of TLR2 gene is genetically controlled and the patients heterozygous for guanine (G) 2258A had reduced production levels of IFN-γ suggesting that altered TLR2 responsiveness might contribute to the course of infections [60–63] and weakened TLR2-IFN-γ signalling have been in differential clinical presentations [42, 44, 64, 65]. This evidence concerns the gene IFNG and infection.