Although 3 patients were responder to sunitinib even high expression of IL13RA2 in their primary tumors, most patients with primary ccRCC tumors of higher IL13RA2 expression were non-responder group when they were treated with sunitinib for metastatic sites compared with those of lower IL13RA2 expression (Fig 2C). This evidence concerns the gene IL13RA2 and nonpapillary renal cell carcinoma.