CASP1 and infection: On the other hand a recent report of Lima-Junior et al. presented data that inflammasomes and IL-1β are involved in the control of L. amazoniensis infections of C57Bl/6 mice as shown by in vitro and in vivo studies using mice and BMDMs of deficient in IL-1β production (including caspase-1 and NLRP3 KO mice) [13].