Ranked according to their significance (P value), they included: pigment epithelium-derived factor (PEDF) signaling, regulation of IL-2 expression in activated and anergic T lymphocytes, ultra-violet A (UVA)-induced MAPK signaling, interferon signaling, the role of tissue factor in cancer ̧ proliferation-inducing ligand (APRIL)-mediated signaling, and p38 MAPK signaling (Fig 3). The gene discussed is IL2; the disease is cancer.