The top 10 canonical pathways, ranked by their significance (P value) included: the role of IL-17A in arthritis, the activation of hepatic fibrosis/hepatic stellate cell, the role of protein kinase receptor (PKR) in interferon induction and antiviral response, the role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, and the role of IL-17F in allergic inflammatory airway diseases. The gene discussed is IL17F; the disease is arthritic joint disease.