The genotype distributions of HapMap-JPT (T allele frequency: 0.322) were closer to those of the HapMap-CHB population, and a study based on a Japanese population reported that there were no association between SIRT6 rs107251 T allele and diabetic nephropathy [39], which is a disease associated with atherosclerosis [40]. This evidence concerns the gene SIRT6 and atherosclerosis.