We have recently described that the glycogenic activity of R6 is regulated by ubiquitination: R6 interacts with laforin, a dual specificity phosphatase involved in Lafora disease (a type of progressive myoclonus epilepsy), which targets R6 to malin, an E3-ubiquitin ligase also related to Lafora disease [17]. The gene discussed is EPM2A; the disease is Lafora disease.