In parallel, reduced cerebral prefrontal cortex protein levels of TrkB and p-Akt and the downstream signals of BDNF-TrkB pathway were found in reserpine pretreated mice, suggesting that BDNF-TrkB signal pathway on cerebral prefrontal cortex may play a major neurobiological role in depression behaviors induced by reserpine. Here, AKT1 is linked to depressive disorder.