MCL1 and acute myeloid leukemia: Much more recently, PIK-75, a compound that transiently blocks CDK7/9, leading to transcriptional suppression of Mcl-1, and also targets the p110α isoform of PI3K has been shown to rapidly induce apoptosis of AML cells, significantly reduce leukemic burden and increase the survival of mouse xenografts without overt toxicity [209].