FLT3 and acute myeloid leukemia: Additionally, JQ1 also synergized with the FLT3 tyrosine kinase inhibitors (TKIs) ponatinib or quizartinib to induce apoptosis of FLT3-ITD+ AML cells and overcame FLT3 TKI resistance-conferring mutations such as F691L and D835V [43].