MTOR and cancer: The phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a cellular growth, proliferation, motility and survival signaling axis [149] that represents one of the most frequently dysregulated pathways in cancer [150], including AML [151,152], where activation of the pathway has been shown to be required for cell survival [153,154].