SETD2 and cancer: However, taken together with a recent report that mutations affecting the epigenetic factor SETD2 are associated with loss of histone H3 lysine 36 tri-methylation (H3K36me3) and increased intron retention in clear cell renal cell carcinoma [19], our results suggest that crosstalk between epigenetics and RNA splicing may link a diverse spectrum of mutations to RNA processing defects in cancer.