Although Tp53−/− mice have been crossed with Eμ-Tcl1 transgenic animals, the resulting compound-mutant Eμ-Tcl1;Tp53−/− mice carried a homozygous germline deletion of Tp53, which limits their use as a preclinical model to mirror somatic del(17p) or TP53-mutation in CLL (Liu et al., 2014). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.