Despite a clear decline of plasma IFNα levels associated with a reversion of the phenotype of CMV- and EBV-specific CD8+ T cells in CHC patients successfully treated with the direct-acting antivirals sofosbuvir as shown here, the frequency and functionality of these cells did not change at FuW12 (data not shown). The gene discussed is IFNA2; the disease is cryohydrocytosis.