The expression of 2B4 was down-regulated but this was only noticeable on CMV- and EBV-specific CD8+ T cells in healthy individuals (fold decrease = 0.68) compared to patients with CHC where they remained fairly stable (fold increase = 1.01; Figures 2C,F; Figure S1 in Supplementary Material). This evidence concerns the gene CD244 and cryohydrocytosis.