High lymph node metastasis (lymph  node ≥ 4: HR = 2.160, P = 0.007), high TNM stage (IIIC: HR = 4.001, P < 0.001), and low RCN of PPP1R12A (RCN < 0.37: HR = 2.186, P = 0.003) were significantly associated with poor RFS. This evidence concerns the gene PPP1R12A and metastatic malignant neoplasm in the lymph nodes.