Our rationale for evaluating the relevance of the FH-linked region to the development of UL was motivated by early linkage studies suggesting the presence in this genomic region of susceptibility loci for UL (Gross et al. 2004), predisposing for prostate cancer (PCaP; OMIM 602759) (Berthon et al. 1998) and for factors affecting the risk of UL such as adiposity (Aissani et al. 2006) and serum level of sex hormone-binding globulin (SHBG) (Ukkola et al. 2002) (Supplementary Figure S6, see section on supplementary data given at the end of this article). This evidence concerns the gene SHBG and prostate carcinoma.