We observed a total of 154 SNPs in the 22 kb-long FH gene (21 variants in coding and regulatory regions) in 113 quality control samples (93 NIEHS-UFS and 20 HLRCC samples) and confirmed the presence of FH mutations (Table 1) in nine of the 18 tested HLRCC probands as previously reported (Smit et al. 2011). Here, FH is linked to hereditary leiomyomatosis and renal cell cancer.