Nonetheless, with two out of the 24 tested UL cases of AA descent carried heterozygous FH mutations, albeit with unknown pathogenicity, screening for FH mutations in the entire NIEHS-UFS sample is worth an undertaking to unequivocally assess the spectrum of FH mutations in nonsyndromic UL and to evaluate the potential contribution of HLRCC to the UL pool in NIEHS-UFS. The gene discussed is FH; the disease is hereditary leiomyomatosis and renal cell cancer.